대한수면연구학회

분당서울대병원 신경과에 2011년 9월 둥지를 틀고 점점 성장하고 있는 연구실로 근적외선 분광법(near-infrared spectroscopy, 이하 NIRS)과 tACS, tDCS, TENS 등의 신경조절술(neuromodulation)을 기반으로 인공지능 기법을 도입하여 수면-뇌 생리 및 질환 기전 연구 및 중재기술 개발에 박차를 가하고 있다. 

1) NIRS 기반 연구

 아교임파계(glymphatic system)의 비침습 지속모니터링을 통해 활성 결정인자 및 중재 요인을 규명하고, 아교임파계 활성 개선을 통한 알츠하이머병 등 신경퇴행성 질환 예방 및 치료법 개발

 수분혈역학 연구를 통해 뇌졸중/뇌부종/두개 뇌압 상승의 조기 현장 진단과 지속 모니터링을 통한 치료 성과 혁신

 NIRS/EEG/EOG 융복합 장비 개발을 통한 새로운 개념의 수면 분석 장비를 개발, 뇌건강척도를 확립

2) Neuromodulation 기반 연구

스트레스/긴장 이완 및 불면증 개선 신경조절술 개발

신경조절술과 인지행동치료의 결합을 통한 새로운 개념의 불면증 디지털치료 플랫폼 개발 

3) 맞춤형 수면무호흡증 치료 플랫폼 개발

스트레스/긴장 이완 및 불면증 개선 신경조절술 개발

신경조절술과 인지행동치료의 결합을 통한 새로운 개념의 불면증 디지털치료 플랫폼 개발 

4) 기타

역학연구(한국수면두통연구; 지역사회기반 안산코호트 연구)

수면임상약물연구

1. Kim KM, Cho SJ, Shin HJ, Yang KI, Kim D, Yun CH, Chu MK. Prevalence, Disability, and Management Patterns of Migraine in Korea: Nationwide Survey Data from 2009 and 2018. J Clin Neurol 2021 Jan;17(1):77-85. https://doi.org/10.3988/jcn.2021.17.1.77

2. Prevalence and characteristics of cutaneous allodynia in probable migraine. 

3. Im HJ, Kim JH, Yun CH, Kim DW, Oh J. Changes in hepcidin serum levels correlate with clinical improvement in idiopathic restless legs syndrome patients. J Clin Med 2020, 9(12), 4115; https://doi.org/10.3390/jcm9124115.

4. Kim REY, Abbott RD, Kim S, Thomas RJ, Yun CH, Kim H, Johnson H, Shin C. Sleep duration, sleep apnea, and gray matter volume. J Geriatr Psychiatry Neurol 2020 in press.

5. Wood C, Bianchi MT, Yun CH, Shin C, Thomas RJ. Multicomponent analysis of sleep using electrocortical, respiratory, autonomic and hemodynamic signals reveals distinct features of stable and unstable NREM and REM sleep. Front Physiol. 2020 Dec 3;11:592978. doi: 10.3389/fphys.2020.592978. eCollection 2020.PMID: 33343390 

6. Kim REY, Kim HJ, Kim S, Abbott RD, Thomas RJ, Yun CH, Lee HW, Shin C. A longitudinal observational population-based study of brain volume associated with changes in sleep timing from middle to late-life. Sleep. 2020 Nov 10:zsaa233. doi: 10.1093/sleep/zsaa233. PMID: 33170277 

7. Lee SU, Lee J, Yoon JE, Kim HJ, Choi JY, Yun CH, Kim JS. Transient homonymous superior quadrantanopsia in nonketotic hyperglycemia: a case report and systematic review. J Clin Neurol. 2020 Oct;16(4):599-604. doi: 10.3988/jcn.2020.16.4.599. PMID: 33029966

8. Shin C, Kim REY, Thomas RJ, Yun CH, Lee SK, Abbott RD. Neck circumference and cerebral gray matter volume. Alzheimer Dis Assoc Disord 2020 May 29. doi: 10.1097/WAD.0000000000000386. PMID: 32483016

9. Lee DH, Kim KM, Cho J, Kim WJ, Yang KI, Yun CH, Chu MK. Impacts of migraine on the prevalence and clinical presentation of depression: a population-based study. J Affect Disord. 2020 Jul 1;272:215-222. doi: 10.1016/j.jad.2020.03.102. Epub 2020 Apr 29. PMID: 32553361

10. Kim KM, Lee DH, Lee EJ, Roh YH, Kim WJ, Cho SJ, Yang KI, Yun CH, Chu MK. Self-reported insomnia as a marker for anxiety and depression among migraineurs: a population-based cross-sectional study. Sci Rep. 2019 Dec 20;9(1):19608. doi: 10.1038/s41598-019-55928-8. PMID: 31863000

11. Kim D, Chang HJ, Lee W, Seo H, Yang KI, Chu MK, Yun CH. Circadian rhythm, sleep quality, and health-related quality of life in Korean middle adults. J Sleep Med 2020;17(1):66-72. Published online: June 30, 2020 DOI: https://doi.org/10.13078/jsm.200005 

12. Kim KM, Kim J, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Excessive daytime sleepiness in tension-type headache: a population study. Front Neurol. 2019 Dec 3;10:1282. doi: 10.3389/fneur.2019.01282. eCollection 2019. PMID: 31849830

13. Im HJ, Baek SH, Yun CH, Chu MK. Time preference of headache attack and chronotype in migraine and tension-type headache: a prospective clinic-based study. Chronobiol Int. 2019 Nov;36(11):1528-1536. doi: 10.1080/07420528.2019.1658202. Epub 2019 Aug 28. PMID: 31456434

14. Choi HS, Min S, Kim S, Bae H, Yoon JE, Hwang I, Oh D, Yun CH, Yoon S. Learning-based instantaneous drowsiness detection using wired and wireless electroencephalography. IEEE Access. 2019 Oct 7;7:146390-146402. INSPEC Accession Number: 19055795. DOI: 10.1109/ACCESS.2019.2946053. Electronic ISSN: 2169-3536. Publisher: IEEE.

15. Yoon DW, Kwon HN, Jin X, Kim JK, Lee SK, Park S, Yun CH, Shin C. Untargeted metabolomics analysis of rat hippocampus subjected to sleep fragmentation. Brain Res Bull. 2019 Aug 13. pii: S0361-9230(19)30008-5. doi: 10.1016/j.brainresbull.2019.08.008. [Epub ahead of print] PMID: 31419538

16. Lee MH, Yun CH, Min A, Hwang YH, Lee SK, Kim DY, Thomas RJ, Han BS, Shin C. Altered structural brain network resulting from white matter injury in obstructive sleep apnea. Sleep. 2019 Jul 1. pii: zsz120. doi: 10.1093/sleep/zsz120. PMID: 31260533

17. Hwang K, Joo JD, Kim YG, Han, JH, Oh CW, Yun CH, Park SH, Kim CY. Risk factors for preoperative and late postoperative seizures in primary supratentorial meningiomas. Clin Neurol Neurosurg 2019 May;180:34-39. https://doi.org/10.1016/j.clineuro.2019.03.007. PMID: 30889470 

18. Sunwoo JS, Shin DS, Hwangbo Y, Kim WJ, Chu MK, Yun CH, Jang T, Yang KI. High risk of obstructive sleep apnea, insomnia, and daytime sleepiness among commercial motor vehicle drivers. Sleep Breath. 2019 Feb 25. doi: 10.1007/s11325-019-01805-7. PMID: 30805834 

19. Kim TJ, Yoon JE, Park JA, Lee SK, Chu MK, Yang KI, Kim WJ, Park SH, Thomas RJ, Shin C, Yun CH. Prevalence and characteristics of restless legs syndrome in Korean adults: a study in two independent samples of the general population. Neuroepidemiology. 2019 Feb 14;52(3-4):193-204. doi: 10.1159/000496839. PMID: 30763945

20. Song TJ, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Sex differences in prevalence, symptoms, impact, and psychiatric comorbidities in migraine and probable migraine: a population-based study. Headache. 2019 Feb;59(2):215-223. doi: 10.1111/head.13470. Epub 2019 Jan 9. PMID: 30623976

21. Hwang K, Kim DG, Paek SH, Kim CY, Yun CH, Oh CW, Juh R, Han JH. Seizures after stereotactic radiosurgery for benign supratentorial meningiomas: an uncontrollable type of seizure? World Neurosurg. 2019 Mar;123:e549-e556. doi: 10.1016/j.wneu.2018.11.211. Epub 2018 Dec 5. PMID: 30528526

22. Oh JH, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Insufficient sleep in tension-type headache: a population study. J Clin Neurol. 2018 Oct;14(4):566-573. doi: 10.3988/jcn.2018.14.4.566. PMID: 30284768

23. Choi HS, Kim S, Oh JE, Yoon JE, Park JA, Yun CH, Yoon S. XGBoost-based instantaneous drowsiness detection framework using multitaper spectral information of electroencephalography. ACM-BCB ’18, August 29 – September 1, 2018, Washington, DC, USA (Conference proceeding)

24. Kim J, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Impact of migraine on the clinical presentation of insomnia: a population-based study. J Headache Pain. 2018 Sep 14;19(1):86. doi: 10.1186/s10194-018-0916-5. PMID: 30218221

25. Song TJ, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Poor sleep quality in migraine and probable migraine: a population study. J Headache Pain. 2018 Jul 25;19(1):58. doi: 10.1186/s10194-018-0887-6. PMID: 30046921

26. Kim R EY, Yun CH, Thomas RJ, Oh JH, Johnson HJ, Kim S, Lee SK, Seo HS, Shin C. Lifestyle-dependent brain change: a longitudinal cohort MRI study. Neurobiol Aging. 2018 Sep;69:48-57. doi:  10.1016/j.neurobiolaging.2018.04.017. Epub 2018 May 7. PMID: 29852410

27. Song TJ, Yun CH, Cho SJ, Kim WJ, Yang KI, Chu MK. Short sleep duration and poor sleep quality among migraineurs: A population-based study. Cephalalgia. 2018 Apr;38(5):855-864. doi: 10.1177/0333102417716936. Epub 2017 Jun 22. PMID: 28641451. 

28. Sunwoo JS, Hwangbo Y, Kim WJ, Chu MK, Yun CH, Yang KI. Prevalence, sleep characteristics, and comorbidities in a population at high risk for obstructive sleep apnea: A nationwide questionnaire study in South Korea. PLoS One. 2018 Feb 28;13(2):e0193549. doi: 10.1371/journal.pone.0193549. eCollection 2018. PMID: 29489913 

29. Koo DL, Nam H, Thomas RJ, Yun CH. Sleep disturbances as a risk factor for stroke. J Stroke. 2018 Jan;20(1):12-32. doi: 10.5853/jos.2017.02887. Epub 2018 Jan 31. Review. PMID: 29402071

1. 인공지능 모바일 헬스 및 비침습적 신경자극 기반의 편두통 예방/ 치료/관리 기술 개발 [한국한업기술진흥원 /국제공동기술개발사업] 2. 뇌세척 기작(아교임파계) 측정 시스템 개발을 통한 뇌 건강 지표와 질환 예측 모델 확립 [한국연구재단 / 중견연구자지원사업] 3. 개인화 된 수면사운드와 뇌파의 상관관계 연구 및 이를 활용한 수면의 질 개선에 대한 효용성 임상 검증 [LG전자] 4. 폐쇄성수면무호흡증에서 맞춤형 중재를 통해 지속적양압기 순응도 향상 평가 연구 [바이탈에어코리아] 5. 한국수면두통연구: 인지장애 및 우울 영향평가 

잠재적협동연구분야: water physiology, cerebral hemodynamics, clinical chemistry, AI, flex electronics 연구원 모집: 현재 수요 없음. 추후 필요 시 공지